De Flora S, Bronzetti G, Weisburger J H
Istituto di Igiene e Medicina Preventiva, Università di Genova, Italy.
Cancer Epidemiol Biomarkers Prev. 1991 Nov-Dec;1(1):95-9.
This conference, attended by scientists from 27 countries, focused on the most recent advances in the field of antimutagenesis and anticarcinogenesis. Particular emphasis was given to the mechanistic approach, which is believed to be an essential prerequisite for a safer and more effective implementation of chemoprevention of cancer and of mutation-related diseases. The arrangement of the six regular sessions basically followed and updated the detailed classification of mechanisms of inhibitors of mutagenesis and carcinogenesis proposed by S. De Flora and C. Ramel (Mutat. Res., 202: 285-306, 1988), covering both extracellular and cellular mechanisms involved in the prevention of mutations and cancer initiation, as well as in the modulation of later stages of the carcinogenesis process. In addition, a workshop was devoted to methodological aspects concerning the modulation of the genotoxic and carcinogenic response. The present report covers the main themes of overview lectures or research communications presented by more than 60 speakers. Most presentations were multi-authored, as the result of collaborative studies, in several cases at the international level, but only the names of speakers will be given.
本次会议有来自27个国家的科学家参加，重点讨论了抗诱变和抗癌变领域的最新进展。特别强调了机制研究方法，该方法被认为是更安全、更有效地实施癌症化学预防和与突变相关疾病预防的必要前提。六场常规会议的安排基本遵循并更新了S. 德弗洛拉和C. 拉梅尔（《突变研究》，202: 285 - 306, 1988）提出的诱变和致癌抑制剂机制的详细分类，涵盖了预防突变和癌症起始以及调节致癌过程后期阶段所涉及的细胞外和细胞机制。此外，一个研讨会专门讨论了关于调节遗传毒性和致癌反应的方法学问题。本报告涵盖了60多位演讲者所作的综述讲座或研究报告的主要主题。由于合作研究，大多数报告是多人合著的，在某些情况下是国际层面的合作，但这里只列出演讲者的名字。
