糖尿病是开角型青光眼的危险因素吗？鹿特丹研究。

Is diabetes mellitus a risk factor for open-angle glaucoma? The Rotterdam Study.

作者信息

de Voogd Simone, Ikram M Kamran, Wolfs Roger C W, Jansonius Nomdo M, Witteman Jacqueline C M, Hofman Albert, de Jong Paulus T V M

机构信息

Department of Epidemiology and Biostatistics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

出版信息

Ophthalmology. 2006 Oct;113(10):1827-31. doi: 10.1016/j.ophtha.2006.03.063. Epub 2006 Aug 1.

DOI:10.1016/j.ophtha.2006.03.063

PMID:16884777

Abstract

PURPOSE

To investigate whether diabetes mellitus is a risk factor for open-angle glaucoma (OAG).

DESIGN

Prospective population-based cohort study.

PARTICIPANTS

Participants ages > or =55 years from the Rotterdam Study, The Netherlands.

METHODS

Participants at risk for incident OAG (iOAG) underwent at baseline (1990-1993) and follow-up (1997-1999) the same ophthalmic examination including intraocular pressure (IOP) measurement, visual field testing, and simultaneous stereo optic disc photography. At baseline, diabetes mellitus was defined as the use of antidiabetic medication and/or a random or postload glucose value > or =11.1 mmol/l. The diagnosis of OAG was made with an algorithm based on optic disc measures and visual fields, independent of the IOP.

MAIN OUTCOME MEASURE

Incident OAG.

RESULTS

In total, 3837 participants without OAG at baseline were reexamined. After a mean follow-up time of 6.5 years, iOAG developed in 87 persons. The relative risk of iOAG associated with baseline diabetes was 0.82 (0.33-2.05). After adjustment for age, gender, follow-up time, IOP, IOP-lowering treatment, body mass index, and systemic hypertension, the relative risk of iOAG was 0.65 (0.25-1.64).

CONCLUSIONS

In this prospective population-based study, diabetes mellitus was not a risk factor for OAG.

摘要

目的

研究糖尿病是否为开角型青光眼（OAG）的危险因素。

设计

基于人群的前瞻性队列研究。

参与者

来自荷兰鹿特丹研究中年龄≥55岁的参与者。

方法

有发生原发性开角型青光眼（iOAG）风险的参与者在基线期（1990 - 1993年）和随访期（1997 - 1999年）接受相同的眼科检查，包括眼压（IOP）测量、视野测试以及同步立体视盘照相。在基线期，糖尿病定义为使用抗糖尿病药物和/或随机血糖或餐后血糖值≥11.1 mmol/L。OAG的诊断采用基于视盘测量和视野的算法，与眼压无关。