Guth P S, Risey J, Briner W, Blair P, Reed H T, Bryant G, Norris C, Housley G, Miller R
Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA.
Ann Otol Rhinol Laryngol. 1990 Jan;99(1):74-9. doi: 10.1177/000348949009900113.
Amino-oxyacetic acid (AOAA) was evaluated as a palliative in tinnitus. Sixty-six patients with tinnitus presumed to be of cochlear origin were given either a placebo or 75 mg of AOAA four times a day for 1 week. Response was evaluated by both audiometric measurement of tinnitus loudness and subjective rating by patients of change or no change in tinnitus severity. Because loudness measurements and self-rating have not been shown to be independent, and since the aim of clinical treatment of tinnitus is the alleviation of subjective distress, greater weight was given to the patient's self-rating. A total of 21% of all patients reported a subjective decrease in tinnitus severity, usually within 3 to 4 days after the start of AOAA use. Patients with tinnitus caused by presbycusis or Meniere's disease were the most likely to respond to AOAA treatment with a reduction in tinnitus severity, whereas those with drug-induced tinnitus were the least likely to respond. Nausea and dysequilibrium were the most common side effects of AOAA use. Of the 21% of patients who responded to AOAA, 71% developed some type of side effect. Amino-oxyacetic acid produces a reduction in the severity of tinnitus in about 20% of patients; however, the incidence of side effects makes the drug unacceptable for clinical use.
氨基氧乙酸（AOAA）被评估用于缓解耳鸣。66名推测为耳蜗源性耳鸣的患者，被给予安慰剂或每天4次、每次75毫克的AOAA，持续1周。通过耳鸣响度的听力测量以及患者对耳鸣严重程度变化或无变化的主观评分来评估反应。由于响度测量和自我评分并非相互独立，且耳鸣临床治疗的目标是减轻主观痛苦，因此更重视患者的自我评分。所有患者中共有21%报告耳鸣严重程度主观上有所减轻，通常在开始使用AOAA后的3至4天内出现。由老年性耳聋或梅尼埃病引起耳鸣的患者最有可能对AOAA治疗产生反应，耳鸣严重程度降低，而药物性耳鸣患者反应的可能性最小。恶心和平衡失调是使用AOAA最常见的副作用。在对AOAA有反应的21%的患者中，71%出现了某种类型的副作用。氨基氧乙酸可使约20%的患者耳鸣严重程度降低；然而，副作用的发生率使该药物不适合临床使用。
