Reed H T, Meltzer J, Crews P, Norris C H, Quine D B, Guth P S
Arch Otolaryngol. 1985 Dec;111(12):803-5. doi: 10.1001/archotol.1985.00800140047008.
Amino-oxyacetic acid, previously shown to cause a reversible loss of hearing sensitivity and a reduction in endocochlear potential, was tried as a palliative in human tinnitus. Because the drug seemed to have a cochlear site of action, patients were selected for the study if their audiograms were indicative of cochlear lesions and if there was a reduction in tinnitus following intravenous lidocaine (lidocaine positive). Ten such patients received either 50 or 75 mg of amino-oxyacetic acid four times a day orally for one week or placebo administered in a random, crossover, double-blind design. Of these ten, three reported subjective lessening of tinnitus. One of those three and two others not reporting subjective lessening of tinnitus showed a substantial improvement in speech discrimination scores while receiving amino-oxyacetic acid but not placebo. One additional patient who did not receive lidocaine also reported a subjective lessening of tinnitus. Four patients who were lidocaine negative showed neither subjective nor objective improvement in tinnitus after treatment with amino-oxyacetic acid.
氨基氧乙酸此前已被证明会导致听力敏感性可逆性丧失和内耳蜗电位降低，现被尝试用于缓解人类耳鸣。由于该药物似乎作用于耳蜗部位，所以若患者的听力图显示有耳蜗病变且静脉注射利多卡因后耳鸣减轻（利多卡因阳性），则被选入该研究。十名此类患者按照随机、交叉、双盲设计，每天口服四次50或75毫克氨基氧乙酸，持续一周，或服用安慰剂。在这十名患者中，三名报告耳鸣主观减轻。这三名患者中的一名以及另外两名未报告耳鸣主观减轻的患者，在服用氨基氧乙酸而非安慰剂时，言语辨别分数有显著提高。另外一名未接受利多卡因治疗的患者也报告耳鸣主观减轻。四名利多卡因阴性的患者在接受氨基氧乙酸治疗后，耳鸣在主观和客观方面均未改善。
