硫化氢：健康与疾病中的多功能分子和治疗靶点。

Hydrogen Sulfide: A Versatile Molecule and Therapeutic Target in Health and Diseases.

机构信息

Department of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.

出版信息

Biomolecules. 2024 Sep 10;14(9):1145. doi: 10.3390/biom14091145.

DOI:10.3390/biom14091145

PMID:39334911

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11430449/

Abstract

In recent years, research has unveiled the significant role of hydrogen sulfide (HS) in many physiological and pathological processes. The role of endogenous HS, HS donors, and inhibitors has been the subject of studies that have aimed to investigate this intriguing molecule. The mechanisms by which HS contributes to different diseases, including inflammatory conditions, cardiovascular disease, viral infections, and neurological disorders, are complex. Despite noteworthy progress, several questions remain unanswered. HS donors and inhibitors have shown significant therapeutic potential for various diseases. This review summarizes our current understanding of HS-based therapeutics in inflammatory conditions, cardiovascular diseases, viral infections, and neurological disorders.

摘要

近年来，研究揭示了硫化氢（HS）在许多生理和病理过程中的重要作用。内源性 HS、HS 供体和抑制剂的作用一直是研究这一有趣分子的主题。HS 如何导致不同疾病的机制很复杂，包括炎症状态、心血管疾病、病毒感染和神经紊乱等。尽管取得了显著进展，但仍有几个问题尚未得到解答。HS 供体和抑制剂已显示出对各种疾病的显著治疗潜力。这篇综述总结了我们目前对炎症状态、心血管疾病、病毒感染和神经紊乱中基于 HS 的治疗的理解。