小鼠白细胞介素-4可拮抗干扰素对病毒介导的小鼠L929成纤维细胞裂解的保护作用。
Murine IL-4 antagonizes the protective effects of IFN on virus-mediated lysis of murine L929 fibroblast cells.
作者信息
Lohoff M, Marsig E, Röllinghoff M
机构信息
Institut für klinische Mikrobiologie der Universität, Erlangen-Nürnberg, FRG.
出版信息
J Immunol. 1990 Feb 1;144(3):960-3.
PMID:1688593
Abstract
IFN-alpha, -beta, and -gamma protect murine fibroblasts from lysis by vesicular stomatitis virus. In this report we show that culture supernatants derived from a Th cell clone of the TH2-type completely block the protective effects of the IFN. The active component in inhibiting IFN is identified to be IL-4. rIL-4 has similar effects as the T cell supernatant.
摘要
α、β和γ干扰素可保护鼠成纤维细胞免受水疱性口炎病毒的裂解。在本报告中，我们表明，源自TH2型T辅助细胞克隆的培养上清液完全阻断了干扰素的保护作用。抑制干扰素的活性成分被鉴定为白细胞介素-4。重组白细胞介素-4具有与T细胞上清液相似的作用。
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