基于沙门氏菌致病岛2易位效应蛋白的重组疫苗。
Recombinant vaccines based on translocated effector proteins of Salmonella Pathogenicity Island 2.
作者信息
Husseiny Mohamed I, Wartha Florian, Hensel Michael
机构信息
Institut für Klinische Mikrobiologie, Immunologie und Hygiene, FAU Erlangen-Nürnberg, Wasserturmstr. 3-5, D-91054 Erlangen, Germany.
出版信息
Vaccine. 2007 Jan 2;25(1):185-93. doi: 10.1016/j.vaccine.2005.11.020. Epub 2005 Nov 22.
Attenuated live Salmonella enterica are useful carriers for the delivery of heterologous antigens for vaccination. Effector proteins translocated by type III secretion systems (T3SS) of Salmonella have been successfully utilized for antigen delivery. Here we investigated the use of effector proteins of the T3SS encoded by Salmonella Pathogenicity Island 2 (SPI2). We observed that the effector protein SseF is suitable for delivery of various fusion proteins with heterologous antigens. The efficiency of this carrier protein was demonstrated in vaccination experiments with fusion proteins with Listeria monocytogenes protective antigens. SseF can thus be used as a versatile vehicle for translocation of heterologous proteins for vaccination.
减毒活肠炎沙门氏菌是用于递送异源抗原进行疫苗接种的有用载体。沙门氏菌III型分泌系统（T3SS）转运的效应蛋白已成功用于抗原递送。在此，我们研究了沙门氏菌致病岛2（SPI2）编码的T3SS效应蛋白的用途。我们观察到效应蛋白SseF适用于递送各种与异源抗原的融合蛋白。这种载体蛋白的效率在与单核细胞增生李斯特菌保护性抗原的融合蛋白的疫苗接种实验中得到了证明。因此，SseF可作为一种通用载体用于转运异源蛋白进行疫苗接种。
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