Chu J Y S, Yung W H, Chow B K C
Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, PRC.
Ann N Y Acad Sci. 2006 Jul;1070:27-50. doi: 10.1196/annals.1317.013.
Secretin holds a unique place in the history of endocrinology and gastrointestinal physiology, as it is the first peptide designated as a hormone. During the last century since its first discovery, the hormonal effects of secretin in the gastrointestinal tract were extensively studied, and its principal role in the periphery was found to stimulate exocrine secretion from the pancreas. Recently, a functional role of secretin in the brain has also been substantiated, with evidence suggesting a possible role of secretin in embryonic brain development. Given that secretin and its receptors are widely expressed in multiple tissues, this peptide should therefore exhibit pleiotrophic functions throughout the body. The present article reviews the current knowledge on the central and peripheral effects of secretin as well as its therapeutic uses.
促胰液素在内分泌学和胃肠生理学史上占据着独特的地位，因为它是首个被认定为激素的肽。自首次发现以来的上个世纪里，促胰液素在胃肠道的激素作用得到了广泛研究，并且发现它在外周的主要作用是刺激胰腺的外分泌。最近，促胰液素在大脑中的功能作用也得到了证实，有证据表明促胰液素在胚胎脑发育中可能发挥作用。鉴于促胰液素及其受体在多种组织中广泛表达，因此这种肽应该在全身发挥多效性功能。本文综述了关于促胰液素的中枢和外周作用及其治疗用途的现有知识。
