Leszczynski Dariusz, Meltz Martin L
Functional Proteomics Group STUK--Radiation and Nuclear Safety Authority, Laippatie 4 FIN-00880 Helsinki Finland.
Proteomics. 2006 Sep;6(17):4674-7. doi: 10.1002/pmic.200600414.
The applicability of high-throughput screening techniques of transcriptomics, proteomics and metabolomics in the search for biological and health effects of electromagnetic fields is a hotly debated issue. On the one hand, use of these modern screening technologies speeds up the discovery process and gives broader insight into biochemical events that follow the exposure to electromagnetic fields. On the other hand these modern screening technologies have the problem of reproducibility and variability between experiments and are prone to produce false positive results. These and other issues concerning the applicability of modern screening technologies were the topic of a workshop held at STUK in 2005 (30 October to 1 November) in Helsinki, Finland, and this Report summarizes the discussions at this workshop.
转录组学、蛋白质组学和代谢组学的高通量筛选技术在探寻电磁场的生物学和健康效应方面的适用性是一个备受争议的问题。一方面,使用这些现代筛选技术加快了发现过程,并能更深入地了解暴露于电磁场后发生的生化事件。另一方面,这些现代筛选技术存在实验间可重复性和变异性的问题,并且容易产生假阳性结果。这些以及其他有关现代筛选技术适用性的问题是2005年10月30日至11月1日在芬兰赫尔辛基的芬兰辐射与核安全局举办的一次研讨会上的主题,本报告总结了该研讨会上的讨论内容。