Georgiev D, Karag'ozov I, Velev M, Makaveeva V
Akush Ginekol (Sofiia). 2006;45(3):59-61.
Three cases of vaginal adenosis after topical 5-fluorouracil therapy for vaginal HPV-associated lesions are reported. Three patients with colposcopic, histologic and viral evidences for subclinical papillomavirus infection (in combination with low-grade vaginal intraepithelial neoplasia in of them) are treated with 5-FU. In follow-up control examinations persistent ulcerations were found without regression after applied therapy. By colposcopic and histologic examinations vaginal adenosis was proved without histories of intrautering DES exposure. After the destructive therapy the reported lesions were regressed without appearance of new lesions in follow-up control examinations. The application of 5-fluorouracil has to be used only in cases of recurrent vaginal warts and in cases of high-grade vaginal intraepithelial neoplasia with strict folow-up cytological and colposcopic control examinations.
报告了3例因阴道HPV相关病变接受局部5-氟尿嘧啶治疗后发生阴道腺病的病例。3例患者经阴道镜、组织学及病毒学检查证实有亚临床乳头瘤病毒感染（其中1例合并低度阴道上皮内瘤变），接受了5-氟尿嘧啶治疗。在随访检查中发现持续溃疡，治疗后未消退。经阴道镜和组织学检查证实为阴道腺病，患者无宫内己烯雌酚暴露史。在采用破坏性治疗后，报告的病变消退，随访检查中未出现新病变。5-氟尿嘧啶仅应用于复发性阴道疣以及高级别阴道上皮内瘤变的病例，并需严格进行细胞学和阴道镜随访检查。
