Krebs H B
Department of Obstetrics and Gynecology, Medical College of Virginia, Richmond.
Obstet Gynecol. 1989 Apr;73(4):657-60.
The records of 59 women with grades 2 and 3 vaginal intraepithelial neoplasia were reviewed to define the role of CO2 laser ablation and topical 5-fluorouracil (5-FU) in the treatment of vaginal intraepithelial neoplasia. The patients in each treatment group were comparable in their personal characteristics and in distribution and severity of the lesions. Thirty-one patients used prophylactic 5-FU. Seventy-eight percent of all patients were free of vaginal intraepithelial neoplasia at the first follow-up examination. The results of treatment were not influenced by the grade of the lesion or previous radiation exposure of the patient. Topical 5-FU appeared to be as effective as laser. Periodic applications of 5-FU (once weekly for 10 weeks) were as effective as 5-FU applied in a continuous fashion (three 7-day courses 1 week apart), and caused fewer side effects.
回顾了59例2级和3级阴道上皮内瘤变女性患者的记录，以确定二氧化碳激光消融和局部应用5-氟尿嘧啶（5-FU）在治疗阴道上皮内瘤变中的作用。每个治疗组的患者在个人特征、病变分布和严重程度方面具有可比性。31例患者使用了预防性5-FU。在首次随访检查时，所有患者中有78%没有阴道上皮内瘤变。治疗结果不受病变分级或患者既往放疗史的影响。局部应用5-FU似乎与激光一样有效。5-FU定期应用（每周一次，共10周）与连续应用（间隔1周进行三个7天疗程）效果相同，且副作用更少。
