Kantrowitz N E, Ellis A K, Bristow M R, Minobe W, Billingham M E, Harrison D C
Department of Pathology, Stanford University Medical Center, California.
J Cardiovasc Pharmacol. 1990 Jan;15(1):82-8. doi: 10.1097/00005344-199001000-00013.
Administration of histamine to rabbits may result in myocardial damage similar to that produced by catecholamines and the anthracycline antibiotics. To explore the mechanisms involved in histamine-mediated myocardial damage, conscious New Zealand white rabbits were pretreated with H1 and H2 receptor blocking agents, alone and in combination, and then administered histamine. Coronary artery blood flow was measured with radiolabeled microspheres in rabbits that received histamine alone, and in those that received an H1 blocking agent and histamine. Rabbits that received an H1 blocking agent had a significant reduction in morphological injury which was scored as follows: grade 1, minimal or no injury; grade 2, moderate; and grade 3, severe injury (mean pathology score = 1.1 +/- 0.28 for histamine alone vs. 0.06 +/- 0.06 with H1 receptor blockade, p less than 0.05). Animals pretreated with H2 receptor blockade (mean pathology score = 1.2 +/- 0.49) were not protected against morphological injury. Coronary blood flow decreased in animals that received histamine alone: control = 2.61 +/- 0.38 vs. 1.80 +/- 0.30 ml/min/g (p less than 0.05), and in animals pretreated with H1 blockade; control = 3.29 +/- 0.34 vs. 1.91 +/- 0.28 ml/min/g (p less than 0.01). We conclude that histamine-mediated myocardial damage appears to be mediated by the H1 receptor system and that this appears to be independent of initial changes in global coronary blood flow.
给兔子注射组胺可能会导致类似于儿茶酚胺和蒽环类抗生素所引起的心肌损伤。为了探究组胺介导的心肌损伤所涉及的机制，对清醒的新西兰白兔单独或联合使用H1和H2受体阻断剂进行预处理，然后注射组胺。用放射性微球测量单独接受组胺的兔子以及接受H1阻断剂和组胺的兔子的冠状动脉血流量。接受H1阻断剂的兔子形态学损伤显著减轻，损伤评分如下：1级，轻微或无损伤；2级，中度；3级，严重损伤（单独使用组胺时平均病理评分为1.1±0.28，而H1受体阻断时为0.06±0.06，p<0.05）。用H2受体阻断剂预处理的动物（平均病理评分为1.2±0.49）未受到形态学损伤的保护。单独接受组胺的动物冠状动脉血流量减少：对照组=2.61±0.38 vs. 1.80±0.30 ml/min/g（p<0.05），接受H1阻断剂预处理的动物也是如此；对照组=3.29±0.34 vs. 1.91±0.28 ml/min/g（p<0.01）。我们得出结论，组胺介导的心肌损伤似乎是由H1受体系统介导的，并且这似乎与整体冠状动脉血流量的初始变化无关。
