Budihna M, Drevensek G, Burjak M, Kocijancic S
Department of Pharmacology and Experimental Toxicology, Medical Faculty, University of Ljubljana, Slovenia.
Pflugers Arch. 1996;431(6 Suppl 2):R217-8. doi: 10.1007/BF02346346.
In isolated rat hearts effects of chloropyramine (CP), histamine H1 antagonist, and famotidine (FA), H2 antagonist, upon two different myocardial injuries, ischaemia-reperfusion and hypoxia-reoxygenation were studied. In both types of injury the effects of drugs were seen mainly during reperfusion and reoxygenation, respectively. During reperfusion neither CP nor FA influenced amplitude of contractions, but CP lowered heart rate, +dp/dtmax and coronary flow. During reoxygenation CP and FA lowered early posthypoxic contractions, whereas CP decreased and FA increased heart rate. CP and FA did not significantly influence the post-ischaemic and posthypoxic lactate dehydrogenase (LDH) release. Present results indicate the existence of H1 and H2 receptors in rat heart as well as their involvement in both types of studied injuries.
研究了组胺H1拮抗剂氯吡胺（CP）和H2拮抗剂法莫替丁（FA）对离体大鼠心脏两种不同心肌损伤（缺血-再灌注和缺氧-复氧）的影响。在这两种损伤类型中，药物的作用分别主要出现在再灌注和复氧期间。在再灌注期间，CP和FA均未影响收缩幅度，但CP降低了心率、最大上升速率（+dp/dtmax）和冠脉流量。在复氧期间，CP和FA降低了缺氧后早期收缩，而CP降低、FA增加了心率。CP和FA对缺血后和缺氧后乳酸脱氢酶（LDH）释放无显著影响。目前的结果表明大鼠心脏中存在H1和H2受体，以及它们参与了两种所研究的损伤类型。
