Eyles Darryl W, Rogers Fiona, Buller Kathryn, McGrath John J, Ko Pauline, French Kathryn, Burne Thomas H J
Queensland Centre for Mental Health Research, Wacol, the School of Biomedical Sciences, The University of Queensland, Brisbane, and Perinatal Research Centre, Royal Brisbane and Women's Hospital, Herston, Australia.
Psychoneuroendocrinology. 2006 Sep;31(8):958-64. doi: 10.1016/j.psyneuen.2006.05.006.
Developmental vitamin D deficiency (DVD) has been shown to alter the orderly pattern of brain development. Even though the period of vitamin D deficiency is restricted to gestation this is sufficient to induce behavioural abnormalities in the adult offspring consistent with those seen in many animal models of schizophrenia. Given that some of these behavioural alterations could also be an indirect result of either impaired maternal hypothalamic pituitary axis (HPA) function (which in turn could influence maternal care) or the result of a permanent alteration in HPA function in the adult offspring we have examined HPA status in both maternal animals and adult offspring. In this study we have established that HPA function is normal in the maternally vitamin D deficient rat. We replicate the behavioural phenotype of hyperlocomotion whilst establishing that HPA function is also unchanged in the adult male offspring. We conclude that the behavioural alterations induced by DVD deficiency are due to some adverse event in brain development rather than via an alteration in stress response.
发育性维生素D缺乏（DVD）已被证明会改变大脑发育的有序模式。尽管维生素D缺乏期仅限于妊娠期，但这足以在成年后代中诱发行为异常，这些异常与许多精神分裂症动物模型中所见的异常一致。鉴于其中一些行为改变也可能是母体下丘脑 - 垂体轴（HPA）功能受损（这反过来可能影响母性行为）的间接结果，或者是成年后代HPA功能永久性改变的结果，我们研究了母体动物和成年后代的HPA状态。在这项研究中，我们确定母体维生素D缺乏的大鼠HPA功能正常。我们复制了运动亢进的行为表型，同时确定成年雄性后代的HPA功能也未改变。我们得出结论，DVD缺乏引起的行为改变是由于大脑发育中的某些不良事件，而不是通过应激反应的改变。
