Eyles Darryl Walter
Queensland Centre for Mental Health Research The Park Centre for Mental Health Wacol Australia.
Queensland Brain Institute University of Queensland St. Lucia Queensland Australia.
JBMR Plus. 2020 Oct 18;5(1):e10419. doi: 10.1002/jbm4.10419. eCollection 2021 Jan.
It has been 20 years since we first proposed vitamin D as a "possible" neurosteroid. Our work over the last two decades, particularly results from our cellular and animal models, has confirmed the numerous ways in which vitamin D differentiates the developing brain. As a result, vitamin D can now confidently take its place among all other steroids known to regulate brain development. Others have concentrated on the possible neuroprotective functions of vitamin D in adult brains. Here these data are integrated, and possible mechanisms outlined for the various roles vitamin D appears to play in both developing and mature brains and how such actions shape behavior. There is now also good evidence linking gestational and/or neonatal vitamin D deficiency with an increased risk of neurodevelopmental disorders, such as schizophrenia and autism, and adult vitamin D deficiency with certain degenerative conditions. In this mini-review, the focus is on what we have learned over these past 20 years regarding the genomic and nongenomic actions of vitamin D in shaping brain development, neurophysiology, and behavior in animal models. © 2020 The Author. published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
自我们首次提出维生素D可能是一种“神经甾体”以来，已经过去了20年。在过去的二十年里，我们的工作，特别是细胞和动物模型实验结果，证实了维生素D在发育中的大脑中发挥作用的多种方式。因此，维生素D现在可以自信地跻身于所有已知的调节大脑发育的甾体之列。其他人则专注于维生素D在成人大脑中可能的神经保护功能。本文整合了这些数据，并概述了维生素D在发育中和成熟大脑中发挥的各种作用的可能机制，以及这些作用如何塑造行为。现在也有充分的证据表明，孕期和/或新生儿维生素D缺乏会增加患神经发育障碍（如精神分裂症和自闭症）的风险，而成人维生素D缺乏则与某些退行性疾病有关。在这篇综述中，重点是我们在过去20年里对维生素D在动物模型中塑造大脑发育、神经生理学和行为方面的基因组和非基因组作用的了解。©2020作者。由Wiley Periodicals LLC代表美国骨与矿物质研究学会出版。
