Ideraabdullah Folami Y, Belenchia Anthony M, Rosenfeld Cheryl S, Kullman Seth W, Knuth Megan, Mahapatra Debabrata, Bereman Michael, Levin Edward D, Peterson Catherine A
Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Department of Nutrition, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
J Endocrinol. 2019 May;241(2):R65-R80. doi: 10.1530/JOE-18-0541.
Vitamin D is an essential nutrient that is metabolized in the body to generate an active metabolite (1,25(OH)2D) with hormone-like activity and highly diverse roles in cellular function. Vitamin D deficiency (VDD) is a prevalent but easily preventable nutritional disturbance. Emerging evidence demonstrates the importance of sufficient vitamin D concentrations during fetal life with deficiencies leading to long-term effects into adulthood. Here, we provide a detailed review and perspective of evidence for the role of maternal VDD in offspring long-term health, particularly as it relates to developmental origins of health and disease (DOHaD). We focus on the roles in neurobehavioral and cardiometabolic disorders in humans and highlight recent findings from zebrafish and rodent models that probe potential mechanisms linking early life VDD to later life health outcomes. Moreover, we explore evidence implicating epigenetic mechanisms as a mediator of this link. Gaps in our current understanding of how maternal VDD might result in deleterious offspring outcomes later in life are also addressed.
维生素D是一种必需营养素，在体内代谢生成具有激素样活性且在细胞功能中发挥高度多样作用的活性代谢物（1,25(OH)2D）。维生素D缺乏（VDD）是一种普遍但易于预防的营养紊乱。新出现的证据表明，胎儿期维生素D浓度充足很重要，缺乏会导致成年后的长期影响。在此，我们对母体VDD在后代长期健康中的作用的证据进行详细综述并提出观点，特别是其与健康和疾病的发育起源（DOHaD）的关系。我们关注其在人类神经行为和心脏代谢紊乱中的作用，并强调斑马鱼和啮齿动物模型的最新发现，这些发现探究了早期生活VDD与后期健康结果之间潜在机制的联系。此外，我们探讨了表明表观遗传机制作为这种联系的介导因素的证据。我们还讨论了目前在理解母体VDD如何可能导致后代成年后出现有害结果方面存在的差距。
