果蝇剂量补偿中的非编码RNA

Non-coding RNA in fly dosage compensation.

作者信息

Deng Xinxian, Meller Victoria H

机构信息

Department of Biological Science, Wayne State University, Detroit, MI 48201, USA.

出版信息

Trends Biochem Sci. 2006 Sep;31(9):526-32. doi: 10.1016/j.tibs.2006.07.007. Epub 2006 Aug 4.

DOI:10.1016/j.tibs.2006.07.007

PMID:16890440

Abstract

Dosage compensation modulates global expression of an X chromosome and is necessary to restore the balance between X-chromosome and autosome expression in both sexes. A central question in the field is how this regulation is directed. Large non-coding RNAs, such as Xist in mammals and roX in flies, have pivotal roles in targeting chromosome-wide modification for dosage compensation. Several recent studies in Drosophila provide new insight into the principles of X-chromosome recognition and the function of non-coding RNA in this process.

摘要

剂量补偿调节X染色体的整体表达，对于恢复两性X染色体与常染色体表达之间的平衡是必要的。该领域的一个核心问题是这种调节是如何实现的。大型非编码RNA，如哺乳动物中的Xist和果蝇中的roX，在靶向全染色体修饰以实现剂量补偿方面具有关键作用。最近在果蝇中的几项研究为X染色体识别原理以及非编码RNA在此过程中的功能提供了新的见解。