Satyavathi Valluri, Ghosh Rupam, Subramanian Srividya
Centre of Excellence for Genetics and Genomics of Silkmoths, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500 001, India.
Indian Institute of Science Education and Research, Bhopal 462023, India.
Noncoding RNA. 2017 Mar 16;3(1):14. doi: 10.3390/ncrna3010014.
Recent advances in modern technology have led to the understanding that not all genetic information is coded into protein and that the genomes of each and every organism including insects produce non-coding RNAs that can control different biological processes. Among RNAs identified in the last decade, long non-coding RNAs (lncRNAs) represent a repertoire of a hidden layer of internal signals that can regulate gene expression in physiological, pathological, and immunological processes. Evidence shows the importance of lncRNAs in the regulation of host-pathogen interactions. In this review, an attempt has been made to view the role of lncRNAs regulating immune responses in insects.
现代技术的最新进展使人们认识到,并非所有遗传信息都编码为蛋白质,包括昆虫在内的每个生物体的基因组都会产生可控制不同生物过程的非编码RNA。在过去十年中发现的RNA中,长链非编码RNA(lncRNA)代表了一层隐藏的内部信号,可在生理、病理和免疫过程中调节基因表达。有证据表明lncRNA在宿主与病原体相互作用的调节中具有重要作用。在这篇综述中,我们试图探讨lncRNA在昆虫免疫反应调节中的作用。