Agarwal Piyush K, Palmer Jeffrey S
Division of Pediatric Urology, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
J Urol. 2006 Sep;176(3):875-81. doi: 10.1016/j.juro.2006.04.021.
We reviewed the current diagnosis, staging and management of testicular and paratesticular neoplasms in prepubertal males.
We performed a medical literature search in English using MEDLINE/PubMed that addressed testicular and/or paratesticular neoplasms in prepubertal males. We then analyzed the literature with respect to individual tumors. We present a concise approach toward the management of these individual tumors.
There is still a predominance of yolk sac tumors in prepubertal males, although some studies suggest that teratomas are more common but underreported due to their benign course in children. Prepubertal males are diagnosed in a fashion similar to that in adult patients with an appropriate history and physical examination. A palpable, nontender mass suggests the diagnosis and prompts scrotal ultrasound and tumor markers. Although treatment for most primary tumors has historically been radical inguinal orchiectomy, most benign tumors can now be managed by testis sparing surgery. The addition of radiation, chemotherapy and/or retroperitoneal lymph node dissection depends on tumor stage and histological type.
Although it is rare in children, any solid scrotal mass in prepubertal males warrants evaluation for possible testicular or paratesticular neoplasm.
我们回顾了青春期前男性睾丸及睾丸旁肿瘤的当前诊断、分期和管理方法。
我们使用MEDLINE/PubMed进行了英文医学文献检索,内容涉及青春期前男性的睾丸和/或睾丸旁肿瘤。然后我们针对各个肿瘤对文献进行了分析。我们提出了一种针对这些个体肿瘤管理的简明方法。
青春期前男性中卵黄囊瘤仍占主导地位,尽管一些研究表明畸胎瘤更为常见,但由于其在儿童中的良性病程而报告不足。青春期前男性的诊断方式与成年患者相似,需进行适当的病史询问和体格检查。可触及的无痛性肿块提示诊断,并促使进行阴囊超声检查和肿瘤标志物检查。尽管历史上大多数原发性肿瘤的治疗方法是根治性腹股沟睾丸切除术,但现在大多数良性肿瘤可以通过保留睾丸手术进行管理。放疗、化疗和/或腹膜后淋巴结清扫术的添加取决于肿瘤分期和组织学类型。
尽管在儿童中很少见,但青春期前男性的任何阴囊实性肿块都需要评估是否可能为睾丸或睾丸旁肿瘤。