他汀类药物用于预防血管外科手术围手术期心血管并发症

Statins for the prevention of perioperative cardiovascular complications in vascular surgery.

作者信息

Schouten Olaf, Bax Jeroen J, Dunkelgrun Martin, Feringa Harm H, van Urk Hero, Poldermans Don

机构信息

Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands.

出版信息

J Vasc Surg. 2006 Aug;44(2):419-24. doi: 10.1016/j.jvs.2006.04.039.

DOI:10.1016/j.jvs.2006.04.039

PMID:16890882

Abstract

Perioperative cardiovascular complications in vascular surgery remain a significant problem despite recent advancements in perioperative care. This clinical update summarizes the results of recent studies on the effectiveness and safety of perioperative statin use for the prevention of these perioperative cardiovascular complications. Five studies in patients undergoing major noncardiac vascular surgery and two studies in patients undergoing carotid endarterectomy are described. All studies reported a significant reduction in perioperative cardiovascular events in statin users compared with nonusers. The safety of perioperative statin use has not yet been fully elaborated, although current evidence suggests there is no extra risk from statin-induced side effects in the perioperative period.

摘要

尽管围手术期护理最近取得了进展，但血管手术中的围手术期心血管并发症仍然是一个重大问题。本临床综述总结了近期关于围手术期使用他汀类药物预防这些围手术期心血管并发症的有效性和安全性的研究结果。文中描述了五项针对接受重大非心脏血管手术患者的研究以及两项针对接受颈动脉内膜切除术患者的研究。所有研究均报告，与未使用他汀类药物的患者相比，使用他汀类药物的患者围手术期心血管事件显著减少。围手术期使用他汀类药物的安全性尚未得到充分阐述，不过目前的证据表明，围手术期他汀类药物引起的副作用不会带来额外风险。