Zhao Qing-Yan, Huang Cong-Xin, Jiang Hong, Yang Bo, Liang Jin-Jun, Chen Hui, Li Geng-Shan
Int J Cardiol. 2007 May 2;117(3):425-6. doi: 10.1016/j.ijcard.2006.05.066. Epub 2006 Aug 4.
The reentrant mechanism of vagally mediated AF is not clearly elucidated.
After vagal stimulation, thirty dogs were divided AF group (AF could be induced) and control group (AF could not be induced). Western blot and patch clamp were used to determine M(2) receptor and I(K,ACh) in left atrial appendage (LAA), right atrial appendage (RAA), left atrium (LA), right atrium (RA), pulmonary veins (PVs) and superior vena cava (SVC). In control group, the densities of M(2) receptor and I(K,ACh) in LAA, RAA and LA were higher than that in RA, PVs and SVC. However, there was no significant difference in LAA, RAA and LA. In AF group, the densities of M(2) receptor and I(K,ACh) in LAA, RAA and LA were higher than that in RA, PVs and SVC. Furthermore, the densities of the M(2) and I(K,ACh) in LAA and RAA were higher than that in LA.
Atrial appendage perhaps play an important role in initiation of cholinergic AF. However, PVs and SVC less often play an important role in vagotonic paroxysmal AF.
迷走神经介导的房颤折返机制尚未完全阐明。
迷走神经刺激后，30只犬被分为房颤组（可诱发房颤）和对照组（不可诱发房颤）。采用蛋白质免疫印迹法和膜片钳技术测定左心耳（LAA）、右心耳（RAA）、左心房（LA）、右心房（RA）、肺静脉（PVs）和上腔静脉（SVC）中的M₂受体和乙酰胆碱激活钾电流（I(K,ACh)）。对照组中，LAA、RAA和LA的M₂受体密度及I(K,ACh)高于RA、PVs和SVC。然而，LAA、RAA和LA之间无显著差异。房颤组中，LAA、RAA和LA的M₂受体密度及I(K,ACh)高于RA、PVs和SVC。此外，LAA和RAA的M₂受体及I(K,ACh)密度高于LA。
心耳可能在胆碱能性房颤的起始中起重要作用。然而，肺静脉和上腔静脉在迷走神经亢进性阵发性房颤中较少起重要作用。
