表皮中的前列腺素和环磷酸腺苷。前列腺素和肾上腺素对正常及银屑病猪和人表皮腺苷酸环化酶系统独立作用的证据。

Prostaglandins and cyclic AMP in epidermis. Evidence for the independent action of prostaglandins and adrenaline on the adenyl cyclase system of pig and human epidermis, normal and psoriatic.

作者信息

Adachi K, Yoshikawa K, Halprin K M, Levine V

出版信息

Br J Dermatol. 1975 Apr;92(4):381-8. doi: 10.1111/j.1365-2133.1975.tb03097.x.

DOI:10.1111/j.1365-2133.1975.tb03097.x

Abstract

Prostaglandins E1 and E2 stimulate cyclic AMP accumulation in pig epidermis and in human epidermis from patients with psoriasis. Prostaglandins A1,A2 and F2alpha are relatively ineffective. The fact that this stimulation is not inhibited by a beta-blocker (propranolol) and that the stimulation by prostaglandin E2 and adrenaline is additive indicates that each drug acts independently on the epidermal adenyl cyclase system. In other words, prostaglandins E1 and E2 act on a site other than the beta-receptor of adenyl cyclase in epidermis. The stimulation by prostaglandins E1 and E2 is not additive; hence they probably act on the same site. Concentrations of prostaglandin E above 3X10(-7) M are effective in causing stimulation. This concentration may be within the physilogical range and the contribution of endogenous prostaglandin levels in the control of intracellular cyclic AMP levels cannot be disregarded.

摘要

前列腺素E1和E2可刺激猪表皮以及银屑病患者的人表皮中环状AMP的积累。前列腺素A1、A2和F2α的作用相对较弱。这种刺激不受β受体阻滞剂（普萘洛尔）抑制，且前列腺素E2和肾上腺素的刺激作用具有相加性，这表明每种药物对表皮腺苷酸环化酶系统的作用是独立的。换句话说，前列腺素E1和E2作用于表皮腺苷酸环化酶β受体以外的位点。前列腺素E1和E2的刺激作用不具有相加性，因此它们可能作用于同一位点。高于3×10⁻⁷ M的前列腺素E浓度可有效引起刺激。该浓度可能在生理范围内，内源性前列腺素水平在控制细胞内环状AMP水平方面的作用不可忽视。