人胃黏膜的腺苷酸环化酶。前列腺素的刺激作用。

Adenylate cyclase of human gastric mucosa. Stimulation by prostaglandins.

作者信息

Simon B, Kather H

出版信息

Res Exp Med (Berl). 1978 Aug 15;173(2):113-7. doi: 10.1007/BF01851868.

Abstract

It has been shown that human gastric mucosa contains a prostaglandin-sensitive adenylate cyclase system. Of the prostaglandins tested the E-type induced an about 3--3.5-fold increase of enzyme activity. The prostaglandin A2 by causing an about 2.5-fold enhancement of cAMP formation and the F-prostaglandins (1.4--2.0-fold stimulation) were less effective in activating the enzyme system. Maximally effective concentrations of histamine and prostaglandin E2 were additive with respect to enzyme activity indicating that both hormones act via individual adenylate cyclases.

摘要

业已表明，人胃黏膜含有一种对前列腺素敏感的腺苷酸环化酶系统。在所测试的前列腺素中，E型前列腺素可使酶活性增加约3至3.5倍。前列腺素A2使环磷酸腺苷（cAMP）生成增加约2.5倍，而F型前列腺素（刺激1.4至2.0倍）激活该酶系统的效果较差。组胺和前列腺素E2的最大有效浓度在酶活性方面具有相加作用，这表明两种激素均通过各自的腺苷酸环化酶起作用。