Yamada Manabu, Kotani Yuri, Nakamura Kikuyasu, Kobayashi Yoshiyasu, Horiuchi Noriyuki, Doi Takuya, Suzuki Satoshi, Sato Norihiro, Kanno Takeshi, Matsui Takane
National Institute of Animal Health, Tsukuba, Japan.
J Vet Med Sci. 2006 Jul;68(7):725-9. doi: 10.1292/jvms.68.725.
The distribution of amyloid deposits was histopathologically and immunohistochemically examined in 25 cows aged 5 to 10 years that had been diagnosed with systemic AA amyloidosis. This examination revealed that amyloid deposits were also present in the hypophysis, ovary, uterus, mammary gland and skeletal muscle, in addition to the liver, kidney, spleen, pancreas, thyroid gland, adrenal gland, gastrointestinal mucosa, heart, lung and lymph nodes. The examined cows tended to have chronic inflammations, including chronic mastitis (six cases) or chronic pneumonia (four cases), which is thought of as a causative agent of AA amyloidosis. In contrast, five cases did not exhibit any chronic inflammation.
对25头年龄在5至10岁、已被诊断患有全身性AA淀粉样变性的奶牛进行了淀粉样沉积物分布的组织病理学和免疫组织化学检查。该检查发现，除肝脏、肾脏、脾脏、胰腺、甲状腺、肾上腺、胃肠道黏膜、心脏、肺和淋巴结外，垂体、卵巢、子宫、乳腺和骨骼肌中也存在淀粉样沉积物。接受检查的奶牛往往患有慢性炎症，包括慢性乳腺炎（6例）或慢性肺炎（4例），这些被认为是AA淀粉样变性的致病因素。相比之下，有5例未表现出任何慢性炎症。
