Choi Changho, Coupland Nicholas J, Kalra Sanjay, Bhardwaj Paramjit P, Malykhin Nikolai, Allen Peter S
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Magn Reson Med. 2006 Sep;56(3):660-5. doi: 10.1002/mrm.20988.
A single-voxel proton NMR J-difference editing method for discriminating between the 1.31 ppm resonances of lactate (Lac) and threonine (Thr) in human brain in vivo at 3 T is reported. One double-band and two triple-band Gaussian 180 degrees RF pulses, all with a bandwidth of 15 Hz, were employed within an adiabatic-refocused double-echo localization sequence to induce the target signals of Lac and Thr and simultaneously acquire a creatine singlet in each subscan. The optimum echo time and the editing efficiency were obtained by numerical analysis of the filtering performance. The Lac and Thr signals were extracted, without lipid contamination, from three subspectra. Using the calculated yields, the concentrations of Lac and Thr in the human occipital cortex were estimated to be 0.47+/-0.07 and 0.56+/-0.06 mM (mean+/-SD, N=7), respectively, with reference to Cr at 8 mM.
报道了一种单体素质子核磁共振J-差异编辑方法，用于在3T场强下对人体大脑中乳酸（Lac）和苏氨酸（Thr）在1.31 ppm处的共振进行体内区分。在绝热重聚焦双回波定位序列中，使用了一个双频带和两个三频带高斯180°射频脉冲，所有脉冲带宽均为15Hz，以诱导Lac和Thr的目标信号，并在每个子扫描中同时采集肌酸单峰。通过对滤波性能的数值分析获得了最佳回波时间和编辑效率。从三个子谱中提取了无脂质污染的Lac和Thr信号。利用计算出的产率，以8mM的Cr为参考，估计人枕叶皮质中Lac和Thr的浓度分别为0.47±0.07和0.56±0.06mM（平均值±标准差，N=7）。
