Galil A, Odes H S
Division of Pediatrics, Soroka-University Hospital, Beer Sheba.
Harefuah. 1990 Jan 1;118(1):10-2.
A 1.5-year-old girl was admitted with chronic diarrhea of 10 months duration and retarded physical and psychomotor development. Duodenal tryptic activity was absent on testing with secretin and cholecystokinin. With pancreatic enzyme replacement diarrhea ceased and growth recommenced. Duodenal tryptic activity returned to normal within 6 months. A 10-year follow-up revealed normal physical and mental growth. Secondary deficiency of trypsin is a rare cause of malabsorption in childhood; correct and timely treatment can avoid severe, irreversible developmental defects.
一名1.5岁女童因持续10个月的慢性腹泻以及身体和精神运动发育迟缓入院。用促胰液素和缩胆囊素检测时，十二指肠胰蛋白酶活性缺失。给予胰腺酶替代治疗后，腹泻停止，生长恢复。十二指肠胰蛋白酶活性在6个月内恢复正常。10年随访显示身体和智力发育正常。胰蛋白酶继发性缺乏是儿童吸收不良的罕见原因；正确及时的治疗可避免严重的、不可逆的发育缺陷。
