Department of Child Health, Medical School University of Indonesia, Jakarta.
Paediatr Indones. 1990 May-Jun;30(5-6):147-53.
A trial using formula Pepti Junior (Nutricia, Holland) containing short chain peptides (SCP) was done for treating 35 children suffering from chronic diarrhoea with protein maldigestion/malabsorption. The other 30 children who suffered from those diseases were treated with non-SCP formula, as a control. Tryptic activity test of duodenal juice was performed 2 or 3 times with a 4-week-interval. The results indicated that the gaining of body weight and improvement of protein maldigestion was better in SCP group compared with non-SCP group (p less than 0.01). However, the acceptance of non-SCP formula was better than SCP formula (p less than 0.05); this might be due to higher tasteless MCT content in the SCP formula. No significant difference was found in duration of diarrhea during the period of treatment between the 2 groups. The explanation of these findings is that the intestinal mucosa can absorb protein better in the form of di- or tripeptide than that of free amino acids, even when the mucosal integrity was impaired due to chronic diarrhoea. It can be concluded that SCP is beneficial for treating protein maldigestion/malabsorption in chronic diarrhoeal children.
一项使用含有短链肽（SCP）的小肽营养粉（纽迪希亚，荷兰）对35名患有慢性腹泻伴蛋白质消化吸收不良的儿童进行治疗的试验。另外30名患有这些疾病的儿童接受不含SCP的配方奶粉治疗，作为对照。十二指肠液的胰蛋白酶活性测试每隔4周进行2至3次。结果表明，与不含SCP的组相比，SCP组的体重增加和蛋白质消化吸收不良改善情况更好（p小于0.01）。然而，不含SCP的配方奶粉的接受度优于SCP配方奶粉（p小于0.05）；这可能是由于SCP配方奶粉中无味中链甘油三酯（MCT）含量较高。两组在治疗期间腹泻持续时间上未发现显著差异。这些发现的解释是，即使由于慢性腹泻导致肠黏膜完整性受损，肠黏膜以二肽或三肽形式吸收蛋白质的能力也优于游离氨基酸形式。可以得出结论，SCP有利于治疗慢性腹泻儿童的蛋白质消化吸收不良。
