de Vries Nienke A, Beijnen Jos H, Boogerd Willem, van Tellingen Olaf
The Netherlands Cancer Institute, Department of Clinical Chemistry, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Expert Rev Neurother. 2006 Aug;6(8):1199-209. doi: 10.1586/14737175.6.8.1199.
The blood-brain barrier (BBB) is of pivotal importance to maintain homeostasis of the CNS, as it closely regulates the composition of the interstitial fluid in the brain. Unfortunately, malignancies that grow within the CNS may evade chemotherapeutic drugs using the same barrier, making this disease refractory to most chemotherapy regimens. This review will outline the impact of the BBB in brain cancer and discuss the efforts that have been made to enhance the drug exposure of brain tumors. Although this review will focus on the role of the BBB in primary brain cancer (malignant glioma), its impact on brain metastases will also be briefly discussed.
血脑屏障（BBB）对于维持中枢神经系统（CNS）的内环境稳定至关重要，因为它密切调节脑间质液的成分。不幸的是，中枢神经系统内生长的恶性肿瘤可能利用同一屏障逃避化疗药物，使得这种疾病对大多数化疗方案具有难治性。本综述将概述血脑屏障在脑癌中的影响，并讨论为提高脑肿瘤药物暴露量所做的努力。尽管本综述将重点关注血脑屏障在原发性脑癌（恶性胶质瘤）中的作用，但也将简要讨论其对脑转移瘤的影响。
