Rizzoli R, Eisman J A, Norquist J, Ljunggren O, Krishnarajah G, Lim S-K, Chandler J
Hopital Cantonal Universitaire de Geneve, Geneva, Switzerland.
Int J Clin Pract. 2006 Aug;60(8):1013-9. doi: 10.1111/j.1742-1241.2006.01066.x.
A serum 25-hydroxyvitamin D [25(OH)D] level of 75 nmol/l (30 ng/ml) has been proposed as the minimum for adequate vitamin D nutrition as lower levels are associated with increases in serum parathyroid hormone in otherwise healthy adults. Amongst 2589 community-dwelling, postmenopausal women with osteoporosis from 18 countries, recruited to determine risk factors for vitamin D inadequacy, 64% had vitamin D inadequacy. General health, education, ethnicity, sun exposure, skin reactivity, diet, recent travel to sunny climates, vitamin D supplementation, body mass index (BMI), season and latitude were assessed using logistic regression models. Asian ethnicity, BMI >or=30 kg/m(2), living in non-equatorial countries, inadequate vitamin D supplementation, poor/fair health, no education about vitamin D, skin reactivity and no recent travel to sunny areas were significant predictors. Several modifiable risk factors are associated with vitamin D inadequacy worldwide, suggesting potentially simple ways to increase vitamin D and improve bone health in postmenopausal women.
血清25-羟维生素D[25(OH)D]水平达到75纳摩尔/升（30纳克/毫升）被认为是维生素D营养充足的最低标准，因为在其他方面健康的成年人中，较低水平与血清甲状旁腺激素升高有关。在来自18个国家的2589名社区居住的绝经后骨质疏松妇女中，这些妇女被招募来确定维生素D不足的风险因素，64%的人存在维生素D不足。使用逻辑回归模型评估了总体健康状况、教育程度、种族、阳光暴露、皮肤反应性、饮食、近期前往阳光充足地区的旅行、维生素D补充剂、体重指数（BMI）、季节和纬度。亚洲种族、BMI≥30千克/平方米、生活在非赤道国家、维生素D补充不足、健康状况差/一般、未接受过维生素D教育、皮肤反应性以及近期未前往阳光充足地区是显著的预测因素。全球范围内，几种可改变的风险因素与维生素D不足有关，这表明可能存在一些简单的方法来增加维生素D并改善绝经后妇女的骨骼健康。
