Kim Ji Sun, Choi Young Eun, Baek Jin Kyung, Cho Ho Jin, Kim Ye Seul
Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Department of Family Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
Korean J Fam Med. 2016 Jul;37(4):221-7. doi: 10.4082/kjfm.2016.37.4.221. Epub 2016 Jul 21.
We examined the relationship between vitamin D status and health-related quality of life, and explored other related factors in the general Korean population.
We used data from the 2007-2012 Korea National Health and Nutrition Examination Survey on 14,104 adults, aged 20-49 years, who had consented to serum vitamin D measurement and answered health-related quality of life questions. EuroQol-5 was used for measurement. Serum vitamin D levels were measured at intervals of 0-9.99, 10-19.99, 20-29.99, and ≥30 ng/mL.
Participants with higher serum vitamin D (serum 25-hydroxyvitamin D) levels were significantly less likely to report problems with depression and anxiety. After adjustment for age, gender, income level, education level, marital status, alcohol consumption, smoking status, and the existence of depressive disorders, the odds ratio for reporting a problem with depression and anxiety was 0.60 (95% confidence interval [CI], 0.39-0.91). The odds ratio for the prevalence of any problem was 0.69 (95% CI, 0.53-0.89) before adjustment, but was not statistically significant after adjustment. No significant associations were observed for problems with mobility, self-care, usual activity, or pain and discomfort.
This is the first study to examine the associations between vitamin D and health-related quality of life for the general Korean population. Vitamin D status was not significantly associated with the dimensions of EuroQol-5 except for depression and anxiety problems.
我们研究了维生素D状态与健康相关生活质量之间的关系，并在韩国普通人群中探索了其他相关因素。
我们使用了2007 - 2012年韩国国家健康与营养检查调查的数据，该调查涉及14104名年龄在20 - 49岁之间的成年人，他们同意进行血清维生素D测量并回答了与健康相关的生活质量问题。采用欧洲五维健康量表（EuroQol - 5）进行测量。血清维生素D水平按0 - 9.99、10 - 19.99、20 - 29.99和≥30 ng/mL的区间进行测量。
血清维生素D（血清25 - 羟基维生素D）水平较高的参与者报告抑郁和焦虑问题的可能性显著降低。在对年龄、性别、收入水平、教育水平、婚姻状况、饮酒情况、吸烟状况和抑郁症的存在进行调整后，报告抑郁和焦虑问题的比值比为0.60（95%置信区间[CI]，0.39 - 0.91）。调整前任何问题患病率的比值比为0.69（95% CI，0.53 - 0.89），但调整后无统计学意义。在活动能力、自我护理、日常活动或疼痛与不适方面未观察到显著关联。
这是第一项研究韩国普通人群中维生素D与健康相关生活质量之间关联的研究。除抑郁和焦虑问题外，维生素D状态与欧洲五维健康量表的维度无显著关联。
