Dembek Z F, Kortepeter M G, Pavlin J A
Department of Medicine, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Epidemiol Infect. 2007 Apr;135(3):353-71. doi: 10.1017/S0950268806007011. Epub 2006 Aug 8.
Public health authorities should be vigilant to the potential for outbreaks deliberately caused by biological agents (bioterrorism). Such events require a rapid response and incorporation of non-traditional partners for disease investigation and outbreak control. The astute application of infectious disease epidemiological principles can promote an enhanced index of suspicion for such events. We discuss epidemiological indicators that should be considered during outbreak investigations, and also examine their application during bioterrorism incidents, an accidental release of an agent, outbreaks of infections that were alleged to have been deliberately initiated, and a model scenario. The Grunow & Finke epidemiological assessment tool is used to examine these historical events and the model scenario. The results received from this analysis, coupled with an understanding of epidemiological clues to unnatural events, and knowledge of how to manage such events, can aid in the improved response and resolution of epidemics.
公共卫生当局应警惕生物制剂蓄意引发疫情（生物恐怖主义）的可能性。此类事件需要迅速做出反应，并纳入非传统合作伙伴进行疾病调查和疫情控制。敏锐地应用传染病流行病学原理可提高对此类事件的怀疑指数。我们讨论了在疫情调查期间应考虑的流行病学指标，并研究了它们在生物恐怖主义事件、制剂意外泄漏、据称是蓄意引发的感染疫情以及一个模拟场景中的应用。使用格鲁诺和芬克流行病学评估工具来审视这些历史事件和模拟场景。从该分析中获得的结果，再加上对非自然事件流行病学线索的理解以及如何管理此类事件的知识，有助于改进对疫情的应对和解决。
