Ferreira P, Pereira R, Coelho J F J, Silva António F M, Gil M H
Departamento de Engenharia Química, Universidade de Coimbra, Polo II, Pinhal de Marrocos, 3030-290 Coimbra, Portugal.
Int J Biol Macromol. 2007 Jan 30;40(2):144-52. doi: 10.1016/j.ijbiomac.2006.06.023. Epub 2006 Jul 5.
Surgical adhesives have been used for several applications, including haemostasis, sealing air leakages and tissue adhesion. The aim of this work was to develop a biodegradable urethane-based bioadhesive containing free isocyanate groups. This material presents the advantage of being biodegradable, biocompatible and having the capacity of reacting with amino groups present in the biological molecules. A urethane based on castor oil (CO) was synthesized by reaction of the molecule with isophorone diisocyanate (IPD). The characterization of the material was accomplished by different techniques: ATR-FT-IR (attenuated transmittance reflection-Fourier transform infrared), swelling capacity determination, evaluation of the moisture curing kinetics, reaction with aminated substrates and determination of surface energy by contact angle measurement. The study of the urethane thermal properties was performed by DMTA (dynamical mechanical thermal analysis) and TGA (thermogravimetric analysis). The haemocompatibility of the urethane was also evaluated by thrombosis and haemolysis tests.
外科粘合剂已用于多种应用，包括止血、封闭漏气和组织粘连。这项工作的目的是开发一种含有游离异氰酸酯基团的可生物降解的聚氨酯基生物粘合剂。这种材料具有可生物降解、生物相容性好以及能够与生物分子中存在的氨基发生反应的优点。通过蓖麻油（CO）分子与异佛尔酮二异氰酸酯（IPD）反应合成了一种基于蓖麻油的聚氨酯。通过不同技术对材料进行了表征：衰减全反射傅里叶变换红外光谱（ATR-FT-IR）、溶胀能力测定、湿气固化动力学评估、与胺化底物的反应以及通过接触角测量确定表面能。通过动态热机械分析（DMTA）和热重分析（TGA）对聚氨酯的热性能进行了研究。还通过血栓形成和溶血试验评估了聚氨酯的血液相容性。
