Bingol Hatice B, Bender Johan C M E, Opsteen Joost A, Leeuwenburgh Sander C G
Department of Dentistry-Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
GATT Technologies BV, Nijmegen, the Netherlands.
Mater Today Bio. 2023 Mar 2;19:100599. doi: 10.1016/j.mtbio.2023.100599. eCollection 2023 Apr.
Biodegradable bone adhesives represent a highly sought-after type of biomaterial which would enable replacement of traditional metallic devices for fixation of bone. However, these biomaterials should fulfil an extremely large number of requirements. As a consequence, bone-adhesive biomaterials which meet all of these requirements are not yet commercially available. Therefore, this comprehensive review provides an extensive overview of the development of bone adhesives from a translational perspective. First, the definition, classification, and chemistry of various types of bone adhesives are highlighted to provide a detailed overview of this emerging class of biomaterials. In this review we particularly focused studies which describe the use of materials that are capable of gluing two pieces of bone together within a time frame of minutes to days. Second, this review critically reflects on i) the experimental conditions of commonly employed adhesion tests to assess bone adhesion and ii) the current state-of-the-art regarding their preclinical and clinical applicability.
可生物降解骨黏合剂是一类备受追捧的生物材料，有望取代用于固定骨骼的传统金属器械。然而，这些生物材料需要满足大量的要求。因此，满足所有这些要求的骨黏合生物材料尚未实现商业应用。因此，本综述从转化医学的角度对骨黏合剂的发展进行了广泛概述。首先，重点介绍了各类骨黏合剂的定义、分类和化学性质，以详细概述这一新兴的生物材料类别。在本综述中，我们特别关注那些描述在数分钟至数天的时间范围内能够将两块骨头黏合在一起的材料使用情况的研究。其次，本综述批判性地反思了：i）用于评估骨黏附的常用黏附测试的实验条件，以及ii）它们在临床前和临床适用性方面的当前技术水平。
