Wunderink Lex, Nienhuis Fokko J, Sytema Sjoerd, Wiersma Durk
Department of Psychiatry, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 R B Groningen, The Netherlands.
Schizophr Bull. 2007 May;33(3):792-6. doi: 10.1093/schbul/sbl015. Epub 2006 Aug 7.
The objective of this study was to examine the predictive validity of the remission criteria proposed by Andreasen et al in first-episode patients responding to antipsychotics. Antipsychotic responsive patients with first-episode schizophrenia showing symptom remission (n = 60) were compared with patients who did not fulfill the proposed criteria (n = 65). Outcome in terms of symptom severity, social functioning, and quality of life was assessed after 18 months. Patients in the remission group showed a significantly better outcome during follow-up on all Positive and Negative Syndrome Scale subscale scores (positive, negative, and general symptom subscales) and a significantly higher level of social functioning. Quality of life did not differ between groups. The proposed multidimensional criteria for symptomatic remission convey significant information when applied to first-episode patients who responded to antipsychotics, predicting outcome on the domains of both psychopathology and social functioning. The criteria represent a practicable benchmark with clinical relevance. Their implementation should be promoted in research settings, clinical practice, and routine outcome assessment procedures.
本研究的目的是检验Andreasen等人提出的缓解标准在首次发作且对抗精神病药物有反应的患者中的预测效度。将首次发作的精神分裂症且对抗精神病药物有反应并出现症状缓解的患者（n = 60）与未达到所提出标准的患者（n = 65）进行比较。18个月后评估症状严重程度、社会功能和生活质量方面的结果。缓解组患者在随访期间所有阳性和阴性症状量表子量表评分（阳性、阴性和一般症状子量表）方面均显示出明显更好的结果，且社会功能水平显著更高。两组之间生活质量没有差异。所提出的症状缓解多维标准应用于对抗精神病药物有反应的首次发作患者时，在心理病理学和社会功能领域都能传达重要信息，预测结果。这些标准代表了具有临床相关性的可行基准。应在研究环境、临床实践和常规结果评估程序中推广其应用。
