Kinjo T, Takashi M, Miyake K, Nagura H
Department of Urology, Nagoya University School of Medicine, Japan.
J Surg Oncol. 1990 Feb;43(2):73-8. doi: 10.1002/jso.2930430203.
Phenotypic characteristics of endothelial cells of blood vessels in renal cell carcinoma were studied immunohistochemically. Vascular endothelial cells in different compartments expressed surface antigens heterogenously. Sinusoidal capillary endothelial cells adjacent to carcinoma cells shared antigens with a monocyte/macrophage subset (OKM5 +, HLA-DR +, interleukin-1 +), but were only faintly positive or absent for factor VIII/von Willebrand factor antigen. Endothelial cells of larger vessels in fibrous septa were OKM5-, HLA-DR +, interleukin-1 +, factor VIII/von Willebrand factor antigen +. Renal cell carcinoma cells expressed HLA-DR and HLA-ABC antigens. These findings suggest that renal cell carcinoma cells are surrounded by blood vessels containing effector cells for immune responses, and that they have a high-potency response to immunopotentiators.
采用免疫组织化学方法研究了肾细胞癌血管内皮细胞的表型特征。不同区域的血管内皮细胞异质性地表达表面抗原。与癌细胞相邻的窦状毛细血管内皮细胞与单核细胞/巨噬细胞亚群（OKM5 +、HLA - DR +、白细胞介素 - 1 +）共有抗原，但对因子VIII/血管性血友病因子抗原仅呈弱阳性或阴性。纤维间隔中较大血管的内皮细胞OKM5 -、HLA - DR +、白细胞介素 - 1 +、因子VIII/血管性血友病因子抗原 +。肾癌细胞表达HLA - DR和HLA - ABC抗原。这些发现提示肾癌细胞被含有免疫反应效应细胞的血管所包围，并且它们对免疫增强剂有高效反应。
