Saito Y, Morise K, Nagura H
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Am J Gastroenterol. 1991 Mar;86(3):297-303.
Microvascular endothelial cells (EnC) in primary B cell lymphoma of the gastrointestinal tract were immunohistochemically studied. Based on the morphological structure, the microvasculatures were divided into high endothelial cell vessels (HEV) and flat endothelial cell vessels (FEV). There were distinct phenotypic differences between HEV and FEV in lymphoma tissues. HEV were characterized as OKM1- OKM5-, accompanied by the cluster of non-neoplastic T lymphocytes, and FEV were OKM1- OKM5+ not accompanied by T lymphocyte infiltration. Factor VIII-related antigen was clearly identified in both EnC, and major histocompatibility complex (MHC) class II antigens and interleukin 1 were absent or only faintly visible on EnC in lymphoma tissues, whereas they were expressed on EnC in non-lymphoma tissues. These findings suggest that microvascular EnC in primary B cell lymphoma of the gastrointestinal tract lack a property as antigen-presenting cells, and that HEV are involved in the migration of non-neoplastic T lymphocytes.
对胃肠道原发性B细胞淋巴瘤中的微血管内皮细胞（EnC）进行了免疫组织化学研究。根据形态结构，微血管分为高内皮细胞血管（HEV）和平坦内皮细胞血管（FEV）。淋巴瘤组织中HEV和FEV存在明显的表型差异。HEV的特征为OKM1 - OKM5阴性，伴有非肿瘤性T淋巴细胞聚集，而FEV为OKM1 - OKM5阳性，不伴有T淋巴细胞浸润。在两种内皮细胞中均能清楚地鉴定出VIII因子相关抗原，淋巴瘤组织中的内皮细胞上主要组织相容性复合体（MHC）II类抗原和白细胞介素1缺失或仅微弱可见，而在非淋巴瘤组织的内皮细胞上则有表达。这些发现表明，胃肠道原发性B细胞淋巴瘤中的微血管内皮细胞缺乏作为抗原呈递细胞的特性，且HEV参与非肿瘤性T淋巴细胞的迁移。
