Gerharz C D, Moll R, Meister P, Knuth A, Gabbert H
Department of Pathology, Johannes Gutenberg-University of Mainz, F.R.G.
Am J Surg Pathol. 1990 Mar;14(3):274-83. doi: 10.1097/00000478-199003000-00009.
We studied an unusual sarcoma with morphologic features diagnostic of epithelioid sarcoma by conventional light microscopy, transmission electron microscopy, and immunohistochemistry. The primary tumor, which was located in the deep soft tissues of the buttock of a 32-year-old woman, and its metastases to lymph nodes, liver, and lung were available for investigation. The histomorphological and ultrastructural appearance of the primary tumor and its metastatic deposits were typical of epithelioid sarcoma. Immunohistochemistry revealed a strong and uniform reactivity for vimentin in both the primary tumor and its metastases. In contrast, a marked cytoskeletal heterogeneity became evident for cytokeratins and neurofilaments, which were observed exclusively in lymph node metastasis. To our knowledge, the observation of neurofilaments in epithelioid sarcoma has not previously been reported.
我们通过传统光学显微镜、透射电子显微镜和免疫组织化学研究了一种具有上皮样肉瘤诊断形态学特征的罕见肉瘤。一名32岁女性臀部深部软组织中的原发性肿瘤及其转移至淋巴结、肝脏和肺部的肿瘤可供研究。原发性肿瘤及其转移灶的组织形态学和超微结构表现均为典型的上皮样肉瘤。免疫组织化学显示，波形蛋白在原发性肿瘤及其转移灶中均呈现强烈且一致的反应性。相比之下，细胞角蛋白和神经丝蛋白的细胞骨架明显异质性，仅在淋巴结转移灶中观察到。据我们所知，上皮样肉瘤中观察到神经丝蛋白此前尚未见报道。
