Ong Mei Shan, Deng Shuo, Halim Clarissa Esmeralda, Cai Wanpei, Tan Tuan Zea, Huang Ruby Yun-Ju, Sethi Gautam, Hooi Shing Chuan, Kumar Alan Prem, Yap Celestial T
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593 Singapore, Singapore.
Cancer Science Institute of Singapore, National University of Singapore, 117599 Singapore, Singapore.
Cancers (Basel). 2020 Jan 18;12(1):238. doi: 10.3390/cancers12010238.
Cytoskeletal proteins, which consist of different sub-families of proteins including microtubules, actin and intermediate filaments, are essential for survival and cellular processes in both normal as well as cancer cells. However, in cancer cells, these mechanisms can be altered to promote tumour development and progression, whereby the functions of cytoskeletal proteins are co-opted to facilitate increased migrative and invasive capabilities, proliferation, as well as resistance to cellular and environmental stresses. Herein, we discuss the cytoskeletal responses to important intracellular stresses (such as mitochondrial, endoplasmic reticulum and oxidative stresses), and delineate the consequences of these responses, including effects on oncogenic signalling. In addition, we elaborate how the cytoskeleton and its associated molecules present themselves as therapeutic targets. The potential and limitations of targeting new classes of cytoskeletal proteins are also explored, in the context of developing novel strategies that impact cancer progression.
细胞骨架蛋白由包括微管、肌动蛋白和中间丝在内的不同蛋白质亚家族组成，对正常细胞和癌细胞的存活及细胞过程至关重要。然而，在癌细胞中，这些机制可能会发生改变以促进肿瘤的发展和进展，细胞骨架蛋白的功能被利用来促进迁移和侵袭能力增强、增殖以及对细胞和环境应激的抗性。在此，我们讨论细胞骨架对重要细胞内应激（如线粒体、内质网和氧化应激）的反应，并描述这些反应的后果，包括对致癌信号传导的影响。此外，我们阐述细胞骨架及其相关分子如何成为治疗靶点。在开发影响癌症进展的新策略的背景下，还探讨了靶向新型细胞骨架蛋白的潜力和局限性。
