Domagala W, Weber K, Osborn M
Department of Tumor Pathology, Medical Academy, Szczecin, Poland.
Acta Cytol. 1988 Jan-Feb;32(1):49-59.
A study was undertaken of the diagnostic significance of the coexpression of intermediate filaments in fine needle aspirates of human tumors. Three types of coexpression were found: (1) true coexpression, in which tumor cells simultaneously express more than one intermediate filament protein; (2) pseudocoexpression, in which various tumor cell types from histogenetically different parts of a complex tumor show different results; and (3) false coexpression, in which tumor cells with one or two types of intermediate filaments are present together with benign cells expressing a different filament type. True coexpression of vimentin and keratin was documented in renal cell carcinomas, endometrial carcinomas, certain thyroid carcinomas and Hürthle cell adenomas. Coexpression of keratin and neurofilaments was seen in Merkel cell carcinomas, and coexpression of desmin and vimentin was found in leiomyosarcomas. Keratin, vimentin and neurofilament expression was seen in medullary thyroid carcinomas, and keratin, vimentin and glial fibrillary acidic protein expression was observed in pleomorphic adenomas of the salivary gland. Pseudocoexpression was noted in synovial sarcoma, epithelioid sarcoma, benign cystosarcoma phyllodes of the breast, teratocarcinoma, malignant granular cell tumor, progonoma, Wilms' tumor and triton tumor. Sources of false coexpression are also discussed.
一项关于人类肿瘤细针穿刺抽吸物中中间丝共表达的诊断意义的研究开展了。发现了三种共表达类型：（1）真正共表达，即肿瘤细胞同时表达一种以上中间丝蛋白；（2）假共表达，即来自复杂肿瘤组织发生学不同部位的各种肿瘤细胞类型显示出不同结果；（3）假阳性共表达，即具有一两种中间丝类型的肿瘤细胞与表达不同丝类型的良性细胞同时存在。在肾细胞癌、子宫内膜癌、某些甲状腺癌和许特耳细胞腺瘤中记录到波形蛋白和角蛋白的真正共表达。在默克尔细胞癌中可见角蛋白和神经丝的共表达，在平滑肌肉瘤中发现结蛋白和波形蛋白的共表达。在甲状腺髓样癌中可见角蛋白、波形蛋白和神经丝表达，在涎腺多形性腺瘤中观察到角蛋白、波形蛋白和胶质纤维酸性蛋白表达。在滑膜肉瘤、上皮样肉瘤、乳腺良性叶状囊肉瘤、畸胎癌、恶性颗粒细胞瘤、原生殖细胞瘤、肾母细胞瘤和蝾螈瘤中注意到假共表达。还讨论了假阳性共表达的来源。
