Govoni S, Goss I, Di Giovine S, Battaini F, Trabucchi M
Department of Pharmacobiology, University of Bari, Italy.
J Neural Transm Gen Sect. 1990;80(1):1-8. doi: 10.1007/BF01245019.
Depolarizing stimuli increase the release of neurotransmitter met-enkephalin from rat striatal slices. Bay K8644, a calcium agonist, significantly enhances the submaximal release of this peptide. Several organic calcium antagonists, including nimodipine, nifedipine, nicardipine, gallopamil and flunarizine, are able to inhibit the potassium-evoked met-enkephalin release both in vitro and ex vivo. The data suggest that the release of this neuropeptide is modulated by calcium antagonist-sensitive calcium channels.
去极化刺激可增加大鼠纹状体切片中神经递质甲硫氨酸脑啡肽的释放。钙激动剂Bay K8644可显著增强该肽的次最大释放。几种有机钙拮抗剂，包括尼莫地平、硝苯地平、尼卡地平、加洛帕米和氟桂利嗪，在体外和体内均能抑制钾诱导的甲硫氨酸脑啡肽释放。数据表明，这种神经肽的释放受钙拮抗剂敏感的钙通道调节。
