Pasinetti G, Govoni S, di Giovine S, Spano P F, Trabucchi M
Brain Res. 1984 Feb 20;293(2):364-7. doi: 10.1016/0006-8993(84)91244-7.
The basal release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is doubled by the in vitro addition of 5 X 10(-5) M dopamine. The K+ evoked release of ME-IR is also slightly enhanced by exposing the slices to dopamine. The effect of dopamine is shared by apomorphine but not by norepinephrine. Neuroleptics do not alter the basal or the K+-stimulated ME-IR release but reverse the dopamine-induced increase. These results suggest that the stimulation of dopamine receptors may influence the enkephalin release within striatum.
体外添加5×10⁻⁵M多巴胺可使大鼠纹状体切片中甲硫氨酸脑啡肽免疫反应性物质（ME-IR）的基础释放量增加一倍。将切片暴露于多巴胺也可使K⁺诱发的ME-IR释放略有增强。阿扑吗啡可产生与多巴胺相同的作用，而去甲肾上腺素则不然。抗精神病药物不会改变基础或K⁺刺激的ME-IR释放，但会逆转多巴胺诱导的增加。这些结果表明，多巴胺受体的刺激可能会影响纹状体内脑啡肽的释放。
