Pine Sharon R, Mechanic Leah E, Bowman Elise D, Welsh Judith A, Chanock Stephen C, Shields Peter G, Harris Curtis C
Laboratory of Human Carcinogenesis, National Cancer Institute, Room 3068, Building 37, 37 Convent Drive, Bethesda, MD 20892-4258, USA.
Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1559-61. doi: 10.1158/1055-9965.EPI-06-0217.
A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been found to be associated with tumor formation. Publication of this null report is important because an association between MDM2 SNP309 and lung cancer was previously reported in two independent studies. Our findings suggest that MDM2 SNP309 is not a strong factor in lung carcinogenesis. In addition, this is the first MDM2 SNP309 report on a population consisting of Caucasians in the United States and African-Americans. A strength of the study design is that the controls consist of both population and hospital controls.
已发现MDM2启动子中的单核苷酸多态性（SNP）（核苷酸309处的T到G交换）与肿瘤形成有关。发表这一无效报告很重要，因为此前在两项独立研究中报道了MDM2 SNP309与肺癌之间的关联。我们的研究结果表明，MDM2 SNP309不是肺癌发生的强相关因素。此外，这是首篇关于美国白人和非裔美国人组成的人群的MDM2 SNP309报告。该研究设计的一个优势在于，对照组包括人群对照和医院对照。
