Plett-Torres T, Cruz-Valdez A, Esquivel-Guadarrama F, Hernández-Nevarez P, Lazcano-Ponce E, Gutiérrez-Xicotencatl L
Center for Research on Infectious Diseases, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Arch Virol. 2007 Jan;152(1):97-114. doi: 10.1007/s00705-006-0829-5. Epub 2006 Aug 3.
The high prevalence of HPV in men's genitalia and the low frequency of virus-associated lesions gave rise to questions on the influence of infection-site on the HPV antibody profile. In a cross-sectional study, HPV infection in penis and urethra, and serum antibodies against HPV-16 E4 and E7 proteins were evaluated in 288 Mexican soldiers. The results showed that HPV prevalence was 31% (51% in penis, 11% in urethra and 38% in both sites), while 47% were multiple infections. Overall, seroprevalence was 13% for anti-E4 antibodies and 6% for anti-E7. However, the highest prevalence of anti-E4 antibodies was observed in men with HPV infection in urethra (30%), while for E7 antibodies, the highest prevalence (10%) was found in men who tested positive for HPV in penis. The prevalence of IgG and IgA anti-E4 was related to HPV-16 urethral infection, while detection of HPV-16 in penis was related to IgG anti-E7 prevalence. In conclusion, the high-risk sexual behavior observed in this population might be responsible for high HPV prevalence and multiple infections. However, the seroprevalence of E4 and E7 was similar to that observed in healthy Mexican women. These results suggest that the humoral immune response against HPV infection in men differs, depending on the site of infection.
人乳头瘤病毒（HPV）在男性生殖器中的高感染率以及与病毒相关病变的低发生率引发了关于感染部位对HPV抗体谱影响的问题。在一项横断面研究中，对288名墨西哥士兵的阴茎和尿道中的HPV感染以及针对HPV-16 E4和E7蛋白的血清抗体进行了评估。结果显示，HPV感染率为31%（阴茎感染率为51%，尿道感染率为11%，两个部位均感染率为38%），而47%为多重感染。总体而言，抗E4抗体的血清阳性率为13%，抗E7抗体的血清阳性率为6%。然而，尿道HPV感染男性中抗E4抗体的阳性率最高（30%），而对于E7抗体，阴茎HPV检测呈阳性的男性中阳性率最高（10%）。IgG和IgA抗E4的阳性率与HPV-16尿道感染有关，而阴茎中HPV-16的检测与IgG抗E7阳性率有关。总之，该人群中观察到的高危性行为可能是HPV高感染率和多重感染的原因。然而，E4和E7的血清阳性率与在健康墨西哥女性中观察到的相似。这些结果表明，男性针对HPV感染的体液免疫反应因感染部位而异。
