Palm Hans-Georg, Bauer Andrea, Weinerth Jutta, Wiedmann Karl Hermann
Medizinische Klinik II, Krankenhaus Barmherzige Brüder, Regensburg.
Med Klin (Munich). 2006 Aug 15;101(8):659-61. doi: 10.1007/s00063-006-1095-8.
Thromboembolic episode, especially cerebral vein thrombosis, is a rare extraintestinal complication of ulcerative colitis. In world literature less than 100 cases are reported. Although the existence of coagulation alterations and fibrinolysis have been suggested, the exact mechanism of hypercoagulability in patients with ulcerative colitis is still unknown.
The authors report of a 35-year-old female patient with ulcerative colitis, that has existed for several years. She developed strong cephalgias without further neurologic symptoms in an acute attack of her disease. Magnetic resonance imaging led to the diagnosis of an extensive acute cerebral vein thrombosis. Other possible reasons for a coagulopathy were excluded.
Cerebral vein thrombosis is a rare, but severe complication of ulcerative colitis. Thus, the presence of neurologic symptoms in a patient with known ulcerative colitis should lead to immediate diagnosis and treatment.
血栓栓塞事件，尤其是脑静脉血栓形成，是溃疡性结肠炎一种罕见的肠外并发症。世界文献报道的病例不到100例。尽管已有研究提示溃疡性结肠炎患者存在凝血改变和纤溶异常，但溃疡性结肠炎患者高凝状态的确切机制仍不清楚。
作者报告了一名35岁的女性溃疡性结肠炎患者，该病已存在数年。在疾病急性发作时，她出现了剧烈头痛，但无其他神经系统症状。磁共振成像诊断为广泛的急性脑静脉血栓形成。排除了其他可能导致凝血病的原因。
脑静脉血栓形成是溃疡性结肠炎一种罕见但严重的并发症。因此，已知患有溃疡性结肠炎的患者出现神经系统症状时应立即进行诊断和治疗。
