Li Li, Li Qinggang, Li Fuli, Shi Quan, Yu Bo, Liu Fengrui, Xu Ping
State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People's Republic of China.
Appl Microbiol Biotechnol. 2006 Dec;73(4):941-8. doi: 10.1007/s00253-006-0530-3. Epub 2006 Aug 9.
Carbazole, carbazoles with monomethyl or dimethyls substituted on different positions (C(1)-carbazoles or C(2)-carbazoles), and benzocarbazoles, as toxic and mutagenic components of petroleum and creosote contamination, were biodegradable by an isolated bacterial strain Pseudomonas sp. XLDN4-9. C(1)-carbazoles were degraded in preference to carbazole and C(2)-carbazoles. The biodegradation of C(1)-carbazoles or C(2)-carbazoles was influenced by the positions of methyl substitutions. Among C(1)-carbazole isomers, 1-methyl carbazole was the most susceptible. C(2)-carbazole isomers with substitutions on the same benzo-nucleus were more susceptible at a concentration of less than 3.4 microg g(-1) petroleum, especially when harboring one substitution on position 1. In particular, 1,5-dimethyl carbazole was the most recalcitrant dimethyl isomer.
咔唑、在不同位置（C(1)-咔唑或C(2)-咔唑）带有单甲基或二甲基取代基的咔唑以及苯并咔唑，作为石油和杂酚油污染中的有毒和致突变成分，可被分离出的细菌菌株假单胞菌属XLDN4-9生物降解。C(1)-咔唑比咔唑和C(2)-咔唑更易降解。C(1)-咔唑或C(2)-咔唑的生物降解受甲基取代位置的影响。在C(1)-咔唑异构体中，1-甲基咔唑最易被降解。在石油浓度低于3.4微克/克时，在同一苯环上有取代基的C(2)-咔唑异构体更易被降解，尤其是在位置1处有一个取代基时。特别是，1,5-二甲基咔唑是最难降解的二甲基异构体。
