Pediconi Federica, Catalano Carlo, Venditti Fiammetta, Ercolani Mauro, Carotenuto Luigi, Padula Simona, Moriconi Enrica, Roselli Antonella, Giacomelli Laura, Kirchin Miles A, Passariello Roberto
Department of Radiological Sciences, University of Rome La Sapienza, Rome, Italy.
Invest Radiol. 2005 Jul;40(7):448-57. doi: 10.1097/01.rli.0000167427.33581.f3.
The objective of this study was to evaluate the value of a color-coded automated signal intensity curve software package for contrast-enhanced magnetic resonance mammography (CE-MRM) in patients with suspected breast cancer.
Thirty-six women with suspected breast cancer based on mammographic and sonographic examinations were preoperatively evaluated on CE-MRM. CE-MRM was performed on a 1.5-T magnet using a 2D Flash dynamic T1-weighted sequence. A dosage of 0.1 mmol/kg of Gd-BOPTA was administered at a flow rate of 2 mL/s followed by 10 mL of saline. Images were analyzed with the new software package and separately with a standard display method. Statistical comparison was performed of the confidence for lesion detection and characterization with the 2 methods and of the diagnostic accuracy for characterization compared with histopathologic findings.
At pathology, 54 malignant lesions and 14 benign lesions were evaluated. All 68 (100%) lesions were detected with both methods and good correlation with histopathologic specimens was obtained. Confidence for both detection and characterization was significantly (P < or = 0.025) better with the color-coded method, although no difference (P > 0.05) between the methods was noted in terms of the sensitivity, specificity, and overall accuracy for lesion characterization. Excellent agreement between the 2 methods was noted for both the determination of lesion size (kappa = 0.77) and determination of SI/T curves (kappa = 0.85).
The novel color-coded signal intensity curve software allows lesions to be visualized as false color maps that correspond to conventional signal intensity time curves. Detection and characterization of breast lesions with this method is quick and easily interpretable.
本研究旨在评估一种用于乳腺对比增强磁共振成像（CE-MRM）的彩色编码自动信号强度曲线软件包在疑似乳腺癌患者中的价值。
对36例经乳腺X线摄影和超声检查怀疑患有乳腺癌的女性患者进行术前CE-MRM评估。CE-MRM在1.5-T磁体上使用二维快速扰相梯度回波（2D Flash）动态T1加权序列进行。以2 mL/s的流速静脉注射0.1 mmol/kg的钆布醇（Gd-BOPTA），随后注入10 mL生理盐水。使用新软件包并分别采用标准显示方法对图像进行分析。对两种方法在病变检测和特征描述方面的置信度以及与组织病理学结果相比的特征描述诊断准确性进行统计学比较。
病理检查时，共评估了54个恶性病变和14个良性病变。两种方法均检测到所有68个（100%）病变，且与组织病理学标本具有良好的相关性。尽管在病变特征描述的敏感性、特异性和总体准确性方面两种方法无差异（P>0.05），但彩色编码方法在检测和特征描述方面的置信度显著更高（P≤0.025）。在病变大小测定（kappa = 0.77）和SI/T曲线测定（kappa = 0.85）方面，两种方法之间均具有极好的一致性。
新型彩色编码信号强度曲线软件可将病变显示为与传统信号强度时间曲线相对应的伪彩色图。用这种方法检测和描述乳腺病变快速且易于解读。
