Padilla Jaume, Harris Ryan A, Fly Alyce D, Rink Lawrence D, Wallace Janet P
Department of Kinesiology, Clinical Exercise Physiology Laboratory, Indiana University, Bloomington, IN 47405, USA.
Eur J Appl Physiol. 2006 Oct;98(3):256-62. doi: 10.1007/s00421-006-0272-z. Epub 2006 Aug 3.
The transient impairment of endothelial function following a high-fat meal is well established. Brachial artery flow-mediated dilation (FMD) decreases between 2 and 6 h post ingestion. Whether this impairment can be reduced with acute aerobic exercise has not been investigated. The purpose of this study was to investigate if a single sustained aerobic exercise session can counteract the postprandial attenuation in brachial artery FMD associated with the ingestion of a high-fat meal. Eight apparently healthy adults (five men, three women), age 25.5 +/- 0.8 years, performed three treatment conditions in a counter-balanced design: (1) low-fat meal alone (LFM), (2) high-fat meal alone (HFM), and (3) one session of aerobic exercise presented 2 h after ingesting a high-fat meal (HFM-EX). The examination of brachial artery FMD was performed at baseline and 4 h following the ingestion of the meal for each treatment condition. A 3 x 2 (treatment x time) repeated measures ANOVA exhibited a significant interaction (P = 0.019). Preprandial FMDs were similar (P = 0.863) among all three treatment conditions. The FMDs following the LFM (7.18 +/- 1.31%) and HFM-EX (8.72 +/- 0.94%) were significantly higher (P = 0.001) than the FMD following the HFM (4.29 +/- 1.64%). FMD was significantly elevated above preprandial values following the HFM-EX (5.61 +/- 1.54 to 8.72 +/- 0.94%, P = 0.005) but was unchanged following the LFM (6.17 +/- 0.94 to 7.18 +/- 1.31%, P = 0.317) and the HFM (5.73 +/- 1.23 to 4.29 +/- 1.64%, P = 0.160). These findings suggest that a single aerobic exercise session cannot only counteract the postprandial endothelial dysfunction induced by the ingestion of a high-fat meal, but also increase brachial artery FMD in apparently healthy adults.
高脂餐后内皮功能的短暂损害已得到充分证实。进食后2至6小时，肱动脉血流介导的舒张功能（FMD）会下降。急性有氧运动是否能减轻这种损害尚未得到研究。本研究的目的是调查单次持续有氧运动是否能抵消与高脂餐摄入相关的餐后肱动脉FMD衰减。八名年龄为25.5±0.8岁的明显健康成年人（五名男性，三名女性），采用平衡设计进行了三种治疗条件：（1）单独低脂餐（LFM），（2）单独高脂餐（HFM），以及（3）在摄入高脂餐后2小时进行一次有氧运动（HFM-EX）。对于每种治疗条件，在基线和进食后4小时进行肱动脉FMD检查。3×2（治疗×时间）重复测量方差分析显示出显著的交互作用（P = 0.019）。所有三种治疗条件下的餐前FMD相似（P = 0.863）。LFM（7.18±1.31%）和HFM-EX（8.72±0.94%）后的FMD显著高于HFM后的FMD（4.29±1.64%）（P = 0.001）。HFM-EX后FMD显著高于餐前值（5.61±1.54至8.72±0.94%，P = 0.005），但LFM（6.17±0.94至7.18±1.31%，P = 0.317）和HFM（5.73±1.23至4.29±1.64%，P = 0.160）后FMD无变化。这些发现表明，单次有氧运动不仅可以抵消高脂餐摄入引起的餐后内皮功能障碍，还可以增加明显健康成年人的肱动脉FMD。
