Günther T, Vormann J, Cragoe E J
Institute of Molecular Biology and Biochemistry, Free University of Berlin, FRG.
FEBS Lett. 1990 Feb 12;261(1):47-51. doi: 10.1016/0014-5793(90)80633-t.
Mg2(+)-loaded rat erythrocytes performed Mn2+/Mg2+ antiport, which was nonspecifically stimulated by anions and cations. Mn2+/Mg2+ antiport was shown to operate via the Na+/Mg2+ antiporter because extracellular Na+ and Mn2+ inhibited the intracellular uptake of each other's ions competitively. Furthermore, Mn2+/Mg2+ antiport and Na+/Mg2+ antiport were identically inhibited by various amiloride derivatives. Na+/Mg2+ antiport of chicken and human erythrocytes cannot perform Mn2+/Mg2+ antiport although chicken erythrocytes took up more Mn2+ than rat erythrocytes.
负载Mg2+的大鼠红细胞进行Mn2+/Mg2+反向转运，该转运受到阴离子和阳离子的非特异性刺激。Mn2+/Mg2+反向转运通过Na+/Mg2+反向转运体起作用，因为细胞外的Na+和Mn2+竞争性抑制彼此离子的细胞内摄取。此外，各种氨氯地平衍生物对Mn2+/Mg2+反向转运和Na+/Mg2+反向转运的抑制作用相同。鸡和人红细胞的Na+/Mg2+反向转运不能进行Mn2+/Mg2+反向转运，尽管鸡红细胞比大鼠红细胞摄取更多的Mn2+。
