Römmele G, Wirz G, Solf R, Vosbeck K, Gruner J, Wehrli W
Research Department, Ciba-Geigy Limited, Basel, Switzerland.
J Antibiot (Tokyo). 1990 Jan;43(1):88-91. doi: 10.7164/antibiotics.43.88.
Sorangicin A, a macrolide polyether antibiotic and the ansamycin antibiotic rifampicin inhibit DNA-dependent RNA polymerase to a similar extent. Resistance to sorangicin A is due to a mutation in the RNA polymerase which renders the enzyme less sensitive. Parallel investigations with rifampicin revealed partial cross-resistance, which was more marked in sorangicin A-resistant mutants than in rifampicin-resistant mutants.
索兰吉星A，一种大环内酯聚醚抗生素，与安莎霉素类抗生素利福平对DNA依赖性RNA聚合酶的抑制程度相似。对索兰吉星A的耐药性是由于RNA聚合酶发生突变，使该酶的敏感性降低。对利福平的平行研究显示存在部分交叉耐药性，这在索兰吉星A耐药突变体中比在利福平耐药突变体中更为明显。
