HIV-1 感染个体中的药物使用与药物依从性
Drug use and medication adherence among HIV-1 infected individuals.
作者信息
Hinkin Charles H, Barclay Terry R, Castellon Steven A, Levine Andrew J, Durvasula Ramani S, Marion Sarah D, Myers Hector F, Longshore Douglas
机构信息
David Geffen School of Medicine, University of California at Los Angeles, 760 Westwood Plaza, Room C8-747, Los Angeles, CA 90024, USA.
出版信息
AIDS Behav. 2007 Mar;11(2):185-94. doi: 10.1007/s10461-006-9152-0.
This longitudinal study examined the impact of drug use and abuse on medication adherence among 150 HIV-infected individuals, 102 who tested urinalysis positive for recent illicit drug use. Medication adherence was tracked over a 6-month period using an electronic monitoring device (MEMS caps). Over the 6-month study drug-positive participants demonstrated significantly worse medication adherence than did drug-negative participants (63 vs. 79%, respectively). Logistic regression revealed that drug use was associated with over a fourfold greater risk of adherence failure. Stimulant users were at greatest risk for poor adherence. Based upon within-participants analyses comparing 3-day adherence rates when actively using versus not using drugs, this appears to be more a function of state rather than trait. These data suggest that it is the acute effects of intoxication, rather than stable features that may be characteristic of the drug-using populace, which leads to difficulties with medication adherence.
这项纵向研究调查了药物使用和滥用对150名感染艾滋病毒个体的药物依从性的影响，其中102人尿液分析近期非法药物使用呈阳性。使用电子监测设备（MEMS瓶盖）在6个月期间跟踪药物依从性。在6个月的研究中，药物检测呈阳性的参与者的药物依从性明显低于药物检测呈阴性的参与者（分别为63%和79%）。逻辑回归显示，药物使用与依从性失败风险高出四倍以上有关。兴奋剂使用者依从性差的风险最大。基于参与者内部分析，比较了积极使用药物与不使用药物时的3天依从率，这似乎更多是状态而非特质的作用。这些数据表明，是中毒的急性影响，而非吸毒人群可能具有的稳定特征，导致了药物依从性方面的困难。
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